Kabir Y, Kimura S
Department of Food Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Nahrung. 1994;38(4):373-7. doi: 10.1002/food.19940380404.
To study the mechanism of action of octacosanol in rats the biodistribution of radioactivity of octacosanol was investigated in response to exercise. The amount of voluntary exercise was significantly higher in octacosanol fed rats than in the control. After ingestion of 14C-octacosanol, the accumulation of radioactivity of octacosanol in the muscle of exercised group given octacosanol was significantly higher in comparison with that of the exercised control group given no octacosanol and also the non-exercised groups irrespective of whether they were given octacosanol or not. The muscle thus seemed to be able to store a considerable amount of octacosanol in response to exercise. Although the exact mechanism of increase in physical exercise caused by octacosanol is not known, it is possible that octacosanol increases the mobilization of free fatty acids from fat cells within muscle. The results indicate that octacosanol possesses an adipokinetic activity, which might affect the lipolysis process of muscle.
为研究二十八烷醇对大鼠的作用机制，研究了二十八烷醇放射性的生物分布与运动的关系。喂食二十八烷醇的大鼠的自主运动量显著高于对照组。摄入14C-二十八烷醇后，与未给予二十八烷醇的运动对照组以及无论是否给予二十八烷醇的非运动组相比，给予二十八烷醇的运动组肌肉中二十八烷醇放射性的积累显著更高。因此，肌肉似乎能够在运动时储存相当数量的二十八烷醇。虽然尚不清楚二十八烷醇导致体育锻炼增加的确切机制，但二十八烷醇可能会增加肌肉内脂肪细胞游离脂肪酸的动员。结果表明，二十八烷醇具有脂肪代谢活性，这可能会影响肌肉的脂肪分解过程。
