Pandey S C, Kim S W, Davis J M, Pandey G N
Illinois State Psychiatric Institute, Chicago 60651.
Biol Psychiatry. 1993 Mar 1;33(5):367-72. doi: 10.1016/0006-3223(93)90326-9.
To examine the role of serotonin-2 (5-HT2) receptors in obsessive-compulsive disorder (OCD), we studied 5-HT2 receptors in platelets obtained from patients with OCD (n = 20) during a drug free baseline period, as well as in normal control subjects (n = 25). The maximum number of binding sites (Bmax) and the apparent dissociation constant (Kd) of 5-HT2 receptors were determined by receptor binding techniques using 125I-lysergic acid diethylamide (LSD) as radioligand. We observed that the mean Bmax of 125I-LSD binding in platelets of patients with OCD was not significantly different when compared with normal control subjects. There was also no significant difference in Kd values between patients with OCD and normal control subjects. To examine whether the baseline 5-HT2 receptors are related to the severity of illness, we determined the relationships of the baseline Bmax and Kd with baseline scores of the Hamilton Depression Rating Scale (HDRS), the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and the National Institute of Mental Health (NIMH) Obsessive-Compulsive scale (GOCS). We found no significant correlation between baseline Bmax and Kd with the baseline HDRS, Y-BOCS, or NIMH-GOCS scores. Our results do not indicate abnormal 5-HT2 receptors in platelets of patients with OCD.
为了研究5-羟色胺-2（5-HT2）受体在强迫症（OCD）中的作用，我们对20例强迫症患者在无药物的基线期采集的血小板以及25例正常对照者的血小板中的5-HT2受体进行了研究。使用125I-麦角酰二乙胺（LSD）作为放射性配体，通过受体结合技术测定5-HT2受体的最大结合位点数量（Bmax）和表观解离常数（Kd）。我们观察到，与正常对照者相比，强迫症患者血小板中125I-LSD结合的平均Bmax无显著差异。强迫症患者与正常对照者之间的Kd值也无显著差异。为了研究基线5-HT2受体是否与疾病严重程度相关，我们确定了基线Bmax和Kd与汉密尔顿抑郁量表（HDRS）、耶鲁-布朗强迫症量表（Y-BOCS）以及美国国立精神卫生研究所（NIMH）强迫症量表（GOCS）的基线评分之间的关系。我们发现基线Bmax和Kd与基线HDRS、Y-BOCS或NIMH-GOCS评分之间无显著相关性。我们的结果并未表明强迫症患者血小板中的5-HT2受体存在异常。
