单次电休克治疗会影响双相I型障碍患者血小板对血清素的摄取。

A single electroconvulsive treatment affects platelet serotonin uptake in bipolar I patients.

作者信息

Marazziti D, Lenzi A, Raffaelli S, Falcone M F, Aglietti M, Cassano G B

机构信息

Institute of Psychiatry, University of Pisa, Italy.

出版信息

Eur Neuropsychopharmacol. 1993 Mar;3(1):33-6. doi: 10.1016/0924-977x(93)90292-t.

DOI:10.1016/0924-977x(93)90292-t

PMID:8471828

Abstract

We evaluated serotonin (5HT) uptake parameters in platelets of a group of bipolar I patients in both a depressive phase and a mixed state, before (t0) and after (t1) the first electroconvulsive treatment (ECT). The results showed the presence of significant changes in the number of the carrier proteins for 5HT at t1, which in most cases preceded the clinical improvement. Although other mechanisms are certainly involved, these data suggest that ECT may influence the 5HT transport through platelet membranes.

摘要

我们评估了一组双相 I 型障碍患者在抑郁期和混合状态下，首次电休克治疗（ECT）前（t0）和后（t1）血小板中血清素（5HT）摄取参数。结果显示，t1 时 5HT 载体蛋白数量存在显著变化，多数情况下这些变化先于临床改善出现。虽然肯定还有其他机制参与其中，但这些数据表明 ECT 可能会影响 5HT 通过血小板膜的转运。