Brusov O S, Dikaia V I, Gubergrits I M, Piatnitskiĭ A N, Zlobina G P, Faktor M I, Pavlova O A, Lideman R R, Panteleeva G P
Zh Nevrol Psikhiatr Im S S Korsakova. 1995;95(4):54-7.
The changes of main platelet serotonergic parameters (maximal velocity of 3H-serotonin uptake, Vmax; and density of (3)3H-imipramine binding sites, Bmax) were followed up in 25 endogenously depressed patients before and after electroconvulsive therapy (ECT). It was found a marked decrease in the velocity of 3H-serotonin uptake into platelets (Vmax) from patients before ECT (especially in non-responder group) and the significant increase of Vmax- and Bmax-values after the course of ECT in responders but not in resistant patients (non-responders). The increase of Vmax- and Bmax-values in responders was evidence of the rise of the functional activity serotonin system after treatment. The results evidence about the significance of serotonergic-mechanisms in the therapeutic efficacy of ECT.
对25例内源性抑郁症患者在电休克治疗（ECT）前后的主要血小板血清素能参数变化（3H-血清素摄取的最大速度，Vmax；以及3H-丙咪嗪结合位点的密度，Bmax）进行了随访。发现ECT前患者血小板摄取3H-血清素的速度（Vmax）显著降低（尤其是在无反应组），ECT疗程后反应者的Vmax和Bmax值显著增加，但抵抗患者（无反应者）未增加。反应者Vmax和Bmax值的增加证明治疗后血清素系统功能活性上升。结果证明血清素能机制在ECT治疗效果中的重要性。
