6号染色体短臂上人类白细胞抗原的区域定位
Regional mapping of the HLA on the short arm of chromosome 6.
作者信息
Berger R, Bernheim A, Sasportes M, Hauptmann G, Hors J, Legrand L, Fellous M
出版信息
Clin Genet. 1979 Mar;15(3):245-51. doi: 10.1111/j.1399-0004.1979.tb00975.x.
Abstract
A detailed gene marker study was performed on a partial 6p trisomic child resulting from a balanced maternal translocation t (2;6) (p 2505; p2105). HLA typing and mixed lymphocyte reaction showed that the breakpoint on chromosome 6 was located within the HLA gene cluster, allowing an accurate location of the D determinants. Localization of the P blood group locus within the region 6 p 2105 to 6 p ter was excluded.
摘要
对一名因母亲平衡易位t(2;6)(p2505;p2105)导致的部分6号染色体三体患儿进行了详细的基因标记研究。HLA分型和混合淋巴细胞反应表明，6号染色体上的断点位于HLA基因簇内，从而能够准确确定D决定簇的位置。排除了P血型位点在6p2105至6p末端区域内的定位。
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