Breuning M H, van den Berg-Loonen E M, Bernini L F, Bijlsma J B, van Loghem E, Meera Khan P, Nijenhuis L E
Hum Genet. 1977 Jun 30;37(2):131-9. doi: 10.1007/BF00393575.
A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21; p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22.
在一个荷兰大家族中进行的一项详细的标记基因研究，该家族存在6号和20号染色体之间的相互易位，即t(6;20)(p21;p13)，结果显示HLA基因与6号染色体短臂上的断点紧密连锁。在这项研究中，HLA与断点之间的连锁在重组值为0.05时获得了明显的峰值lod分数2.9，这表明携带HLA基因的染色体区域位于6p21带靠近向6p22过渡处的断点附近。
