Steiner M
Division of Hematology, Brown University, Providence, Rhode Island.
Clin Cardiol. 1993 Apr;16(4 Suppl 1):I16-8. doi: 10.1002/clc.4960161306.
The effect of vitamin E on platelet function has been reviewed. Although vitamin E inhibits platelet aggregation in vitro, in vivo it has no significant effect when administered in doses up to 1200 U/day. Platelet adhesion, on the contrary, is strongly inhibited by alpha-tocopherol. Doses of 400 IU/day provide greater than 75% inhibition of platelet adhesion to a variety of adhesive proteins when tested at low shear rate in a laminar flow chamber. The antiadhesive effect of vitamin E appears to be related to a reduction in the number and size of pseudopodia upon platelet activation. This effect of vitamin E may be related to changes in fatty acylation of structural platelet proteins. Clinical studies of vitamin E supplementation in patients with thromboembolic disease are in progress.
维生素E对血小板功能的影响已被综述。虽然维生素E在体外可抑制血小板聚集，但在体内，每天给予高达1200单位的剂量时并无显著作用。相反，α-生育酚可强烈抑制血小板黏附。在层流室中以低剪切速率进行测试时，每天400国际单位的剂量可使血小板对多种黏附蛋白的黏附抑制率超过75%。维生素E的抗黏附作用似乎与血小板激活时伪足数量和大小的减少有关。维生素E的这种作用可能与血小板结构蛋白的脂肪酰化变化有关。关于对血栓栓塞性疾病患者补充维生素E的临床研究正在进行中。
