Jackson M A, Lanser A C
Fermentation Biochemistry Research, USDA Agricultural Research Service, Peoria, Illinois 61604.
FEMS Microbiol Lett. 1993 Mar 15;108(1):69-73. doi: 10.1111/j.1574-6968.1993.tb06075.x.
A fusarin C-producing Fusarium moniliforme strain was grown in submerged culture with defined media containing differing amounts of glucose (30 g/l or 90 g/l) and zinc (5 ppb or 3200 ppb). The influence of zinc on fusarin C synthesis and lipid composition was dependent on the initial glucose concentration. In cultures supplied with 30 g/l glucose, zinc inhibited fusarin C and lipid synthesis by diverting common substrates to ethanol synthesis. Zinc-supplemented cultures with 90 g/l glucose had ample carbon substrate to produce both ethanol and fusarin C. More total lipid with a higher unsaturated fatty acid content (more oleic acid and less stearic acid) was found in F. moniliforme biomass produced in zinc-deficient media.
一株产镰刀菌素C的串珠镰刀菌菌株在含有不同葡萄糖量（30克/升或90克/升）和锌量（5 ppb或3200 ppb）的特定培养基中进行深层培养。锌对镰刀菌素C合成和脂质组成的影响取决于初始葡萄糖浓度。在供应30克/升葡萄糖的培养物中，锌通过将常见底物转向乙醇合成来抑制镰刀菌素C和脂质合成。添加锌的90克/升葡萄糖培养物有充足的碳底物来同时产生乙醇和镰刀菌素C。在缺锌培养基中产生的串珠镰刀菌生物量中发现了更多总脂质，其不饱和脂肪酸含量更高（油酸更多，硬脂酸更少）。
