Ho P C, Kwan M S
Department of Obstetrics and Gynaecology, University of Hong Kong.
Hum Reprod. 1993 Mar;8(3):389-92. doi: 10.1093/oxfordjournals.humrep.a138057.
A prospective randomized study was conducted at the Family Planning Association of Hong Kong to compare the efficacy of the Yuzpe regimen and levonorgestrel (0.75 mg for two doses 12 h apart) in post-coital contraception. A total of 424 subjects were recruited into the Yuzpe group and 410 subjects into the levonorgestrel group; 77 subjects in the Yuzpe group and 79 subjects in the levonorgestrel group had further acts of intercourse during the treatment cycle. Fifteen pregnancies (3.5%) occurred in the Yuzpe group and 12 pregnancies (2.9%) in the levonorgestrel group. After excluding the patients who had further acts of intercourse, the failure rates in the Yuzpe group and the levonorgestrel group were 2.6 and 2.4% respectively. The incidence of nausea, vomiting and fatigue in the Yuzpe group was significantly higher than those in the levonorgestrel group. We conclude that levonorgestrel is an effective drug for post-coital contraception with a lower incidence of side-effects than the Yuzpe regimen.
香港计划生育协会开展了一项前瞻性随机研究，以比较Yuzpe方案与左炔诺孕酮（0.75毫克，分两剂，间隔12小时）在性交后避孕中的效果。Yuzpe组共招募了424名受试者，左炔诺孕酮组招募了410名受试者；Yuzpe组有77名受试者，左炔诺孕酮组有79名受试者在治疗周期内有再次性交行为。Yuzpe组发生了15例妊娠（3.5%），左炔诺孕酮组发生了12例妊娠（2.9%）。排除有再次性交行为的患者后，Yuzpe组和左炔诺孕酮组的失败率分别为2.6%和2.4%。Yuzpe组恶心、呕吐和疲劳的发生率显著高于左炔诺孕酮组。我们得出结论，左炔诺孕酮是一种有效的性交后避孕药物，其副作用发生率低于Yuzpe方案。
