Sierra D H
Department of Biomedical Engineering, School of Engineering, University of Alabama, Birmingham 35294.
J Biomater Appl. 1993 Apr;7(4):309-52. doi: 10.1177/088532829300700402.
Fibrin sealants (FS) are the most successful tissue adhesives to date. They have many advantages over adhesive technologies such as cyanoacrylates and marine adhesives in terms of biocompatibility, biodegradation and hemostasis. There are several commercial products in Europe but none in the United States due to the current regulatory stance against pooled plasma blood products. Blood banks and interested investigators have implemented single- and patient autologous-donor production methods with some success. This article will review the history of FS research and development and describe the chemistry of fibrin(ogen) and the production of commercial and research products. Fibrin sealant and purified fibrin characterization is compared and contrasted. The material and adhesive properties are described, and a survey of the clinical applications in which FS has been used is included as well.
纤维蛋白密封剂（FS）是迄今为止最成功的组织粘合剂。在生物相容性、生物降解性和止血方面，它们比氰基丙烯酸酯和海洋粘合剂等粘合技术具有许多优势。欧洲有几种商业产品，但由于目前对混合血浆血液制品的监管立场，美国没有此类产品。血库和感兴趣的研究人员已经实施了单供体和患者自体供体生产方法，并取得了一些成功。本文将回顾FS的研发历史，描述纤维蛋白（原）的化学性质以及商业和研究产品的生产过程。对纤维蛋白密封剂和纯化纤维蛋白的特性进行了比较和对比。描述了其材料和粘合特性，并对FS已被应用的临床应用进行了调查。
