Franzen D, Geisel J, Höpp H W, Oette K, Hilger H H
Klinik III für Innere Medizin, Universität zu Köln.
Med Klin (Munich). 1993 Mar 15;88(3):134-8.
In a prospective and double-blind study, the long-term effects of low dose fish oil on serum lipids and lipoproteins was tested in patients with normal or moderately elevated serum lipids and compared to the effects of olive oil. The compliance to the study medication was evaluated by analysis of serum fatty acids and proved to be very good. Dietary supplementation with 9 g fish oil, respective 3.15 g n-3 fatty acids per day over one year resulted in a decrease of serum-triglycerides by 26% and increase of HDL-cholesterol by 26%. Treatment with 9 g olive oil resulted in an 18% increase of HDL-cholesterol. There was no effect on serum-triglyceride levels.
在一项前瞻性双盲研究中，对血脂正常或轻度升高的患者测试了低剂量鱼油对血脂和脂蛋白的长期影响，并与橄榄油的影响进行了比较。通过分析血清脂肪酸评估对研究药物的依从性，结果证明依从性非常好。每天补充9克鱼油（相当于3.15克n-3脂肪酸），持续一年，可使血清甘油三酯降低26%，高密度脂蛋白胆固醇升高26%。服用9克橄榄油可使高密度脂蛋白胆固醇升高18%。对血清甘油三酯水平没有影响。
