Lukácová N, Chavko M, Halát G
Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovakia.
Neuropharmacology. 1993 Mar;32(3):235-41. doi: 10.1016/0028-3908(93)90106-d.
Stobadine, a drug with the pyridoindol structure, was compared with thiopental and pentobarbital for its ability to inhibit stimulated peroxidation in homogenates of spinal cord in vitro. The antioxidative capacity of the drug exceeded that of barbiturates more than 100-fold. Stobadine was also shown to inhibit the increase in formation of TBA-RS in homogenates of rabbit spinal cord, subjected to 20 min ischaemia, to the level comparable with controls. Administration of the drug (6 mg kg-1) to animals 5 min before 20 min ischaemia had no effect on level of lipid peroxidation products in the spinal cord; however, it slowed down stimulated Fe(2+)-dependent peroxidation after in vitro incubation of the homogenates and increased the concentration of phosphatidylserine and ethanolamine plasmalogens, as compared with non-treated animals. Application of stobadine 2 min before the release of an aortic occlusion increased the antiradical capacity in homogenates of spinal cord and revealed an ameliorating effect on the composition of phospholipids.
斯托巴丁是一种具有吡啶并吲哚结构的药物，在体外对脊髓匀浆中刺激的过氧化作用的抑制能力方面，与硫喷妥钠和戊巴比妥进行了比较。该药物的抗氧化能力超过巴比妥类药物100多倍。斯托巴丁还被证明可抑制家兔脊髓匀浆在经历20分钟缺血后硫代巴比妥酸反应物（TBA-RS）形成的增加，使其水平与对照组相当。在20分钟缺血前5分钟给动物注射该药物（6毫克/千克）对脊髓中脂质过氧化产物水平没有影响；然而，与未治疗的动物相比，它在体外孵育匀浆后减缓了刺激的铁（II）依赖性过氧化作用，并增加了磷脂酰丝氨酸和乙醇胺缩醛磷脂的浓度。在松开主动脉阻断前2分钟应用斯托巴丁可增加脊髓匀浆中的抗自由基能力，并对磷脂组成显示出改善作用。
