Wang X, Dockery D W, Wypij D, Fay M E, Ferris B G
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.
Pediatr Pulmonol. 1993 Feb;15(2):75-88. doi: 10.1002/ppul.1950150204.
Pulmonary function of children aged 6-18 years is described based on 82,462 annual measurements of forced vital capacity (FVC), forced expired volume in 1 second (FEV1), and forced expiratory flow between 25% and 75% of FVC (FEF25-75%) from 11,630 white children and 989 black children. Median height, FVC, FEV1, FEV1/FVC, and FEF25-75% for each 3 months of age are compared among race and sex subgroups. Race- and sex-specific percentile distributions of FVC, FEV1, FEV1/FVC, and FEF25-75% are presented for each centimeter of height (growth curves). For the same height, boys have greater lung function values than girls, and whites have greater ones than blacks. Lung function increases linearly with age until the adolescent growth spurt at about age 10 years in girls and 12 in boys. The pulmonary function vs. height relationship shifts with age during adolescence. Thus, a single equation or the pulmonary function-height growth chart alone does not completely describe growth during the complex adolescent period. Nevertheless, race- and sex-specific growth curves of pulmonary function vs. height make it easy to display and evaluate repeated measures of pulmonary function for an individual child. Race-, sex-, and age-specific regression equations based on height are provided, which permit the evaluation of growth during adolescence with improved accuracy and, more importantly, in comparison with previous observations for the same child.
基于对11630名白人儿童和989名黑人儿童每年进行的82462次肺活量(FVC)、第1秒用力呼气容积(FEV1)以及FVC的25%至75%之间的用力呼气流量(FEF25 - 75%)测量,描述了6至18岁儿童的肺功能。比较了种族和性别亚组中每3个月年龄的中位身高、FVC、FEV1、FEV1/FVC和FEF25 - 75%。给出了FVC、FEV1、FEV1/FVC和FEF25 - 75%针对每厘米身高的种族和性别特异性百分位数分布(生长曲线)。对于相同身高,男孩的肺功能值高于女孩,白人高于黑人。肺功能随年龄呈线性增加,直到女孩约10岁、男孩约12岁时的青春期生长突增。青春期期间,肺功能与身高的关系随年龄变化。因此,单一方程或仅肺功能 - 身高生长图表并不能完全描述复杂青春期的生长情况。然而,肺功能与身高的种族和性别特异性生长曲线便于展示和评估单个儿童的多次肺功能测量值。提供了基于身高的种族、性别和年龄特异性回归方程,这使得能够更准确地评估青春期的生长情况,更重要的是,可与同一儿童以前的观察结果进行比较。