Amiji M, Park K
Purdue University, School of Pharmacy, West Lafayette, IN 47907.
J Biomater Sci Polym Ed. 1993;4(3):217-34. doi: 10.1163/156856293x00537.
Appropriate surface modification has significantly improved the blood compatibility of polymeric biomaterials. This article reviews methods of surface modification with water-soluble polymers, such as polyethylene oxide (PEO), albumin, and heparin. PEO is a synthetic, neutral, water-soluble polymer, while albumin and heparin are a natural globular protein and an anionic polysaccharide, respectively. When grafted onto the surface, all three macromolecules share a common feature to reduce thrombogenicity of biomaterials. The reduced thrombogenicity is due to the unique hydrodynamic properties of the grafted macromolecules. In aqueous medium, surface-bound water-soluble polymers are expected to be highly flexible and extend into the bulk solution. Biomaterials grafted with either PEO, albumin, or heparin are able to resist plasma protein adsorption and platelet adhesion predominantly by a steric repulsion mechanism.
适当的表面改性显著提高了聚合物生物材料的血液相容性。本文综述了用水溶性聚合物进行表面改性的方法，如聚环氧乙烷（PEO）、白蛋白和肝素。PEO是一种合成的中性水溶性聚合物，而白蛋白和肝素分别是天然球状蛋白和阴离子多糖。当接枝到表面时，这三种大分子都具有降低生物材料血栓形成性的共同特征。血栓形成性降低是由于接枝大分子独特的流体动力学性质。在水性介质中，表面结合的水溶性聚合物预计具有高度柔韧性并延伸到本体溶液中。接枝有PEO、白蛋白或肝素的生物材料主要通过空间排斥机制能够抵抗血浆蛋白吸附和血小板粘附。
