Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Division of Bio-Medical Science and Technology, Korea University of Science and Technology (UST), Deajeon, Republic of Korea.
Adv Exp Med Biol. 2020;1250:189-198. doi: 10.1007/978-981-15-3262-7_13.
Bulk blending is considered as one of the most effective and straightforward ways to improve the hemo-compatibility of blood-contacting polymeric biomaterials among many surface modification methods. Zwitterionic structure-, glycocalyx-like structure-, and heparin-like structure-based oligomers have been synthesized as additives and blended with base polymers to improve the blood compatibility of base polymers. Fluorinated end- and side-functionalized oligomers could promote the migration of functionalized groups to the surface of biomedical polymers without changing their bulk properties, and it highly depends on the number and concentration of functional groups. Moreover, oligomers having both zwitterion and fluorine are receiving considerable attention due to their desirable phase separation, which can avoid undesired protein adsorption and platelet adhesion. The surface analysis of the surface-modified materials is usually investigated by analytical tools such as contact angle measurement, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). Blood compatibility is mainly evaluated via platelet adhesion and protein adsorption test, and the result showed a significant decrease in the amount of undesirable adsorption. These analyses indicated that surface modification using bulk blending technique effectively improves blood compatibility of polymeric biomaterials.
批量共混被认为是改善与血液接触的聚合物生物材料血液相容性的最有效和最直接的方法之一，在众多表面改性方法中。已经合成了具有两性离子结构、糖萼样结构和肝素样结构的低聚物作为添加剂，并与基础聚合物共混，以提高基础聚合物的血液相容性。氟化端基和侧基官能化低聚物可以促进官能团向生物医学聚合物表面迁移，而不改变其本体性质，这高度依赖于官能团的数量和浓度。此外，由于其理想的相分离，同时具有两性离子和氟的低聚物受到了相当大的关注，这可以避免不期望的蛋白质吸附和血小板黏附。表面改性材料的表面分析通常通过接触角测量、原子力显微镜 (AFM) 和 X 射线光电子能谱 (XPS) 等分析工具进行研究。血液相容性主要通过血小板黏附和蛋白质吸附试验进行评估，结果表明不期望的吸附量显著减少。这些分析表明，使用批量共混技术进行表面改性可有效提高聚合物生物材料的血液相容性。
