Chou Ying-Nien, Yang I-Hsun
Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan.
Biomimetics (Basel). 2023 May 10;8(2):198. doi: 10.3390/biomimetics8020198.
This study developed an epoxy-type biomimic zwitterionic copolymer, poly(glycidyl methacrylate) (PGMA)-poly(sulfobetaine acrylamide) (SBAA) (poly(GMA-co-SBAA)), to modify the surface of polyamide elastic fabric using a hydroxylated pretreatment zwitterionic copolymer and dip-coating method. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy confirmed successful grafting, while scanning electron microscopy revealed changes in the surface pattern. Optimization of coating conditions included controlling reaction temperature, solid concentration, molar ratio, and base catalysis. The modified fabric exhibited good biocompatibility and anti-biofouling performance, as evidenced by contact angle measurements and evaluation of protein adsorption, blood cell, and bacterial attachment. This simple, cost-effective zwitterionic modification technology has high commercial value and is a promising approach for surface modification of biomedical materials.
本研究开发了一种环氧型仿生两性离子共聚物，聚甲基丙烯酸缩水甘油酯（PGMA）-聚磺酸甜菜碱丙烯酰胺（SBAA）（聚（GMA-co-SBAA）），采用羟基化预处理两性离子共聚物和浸涂法对聚酰胺弹性织物表面进行改性。X射线光电子能谱和傅里叶变换红外光谱证实了接枝成功，而扫描电子显微镜揭示了表面图案的变化。涂层条件的优化包括控制反应温度、固体浓度、摩尔比和碱催化。通过接触角测量以及蛋白质吸附、血细胞和细菌附着的评估证明，改性织物具有良好的生物相容性和抗生物污染性能。这种简单、经济高效的两性离子改性技术具有很高的商业价值，是生物医学材料表面改性的一种有前景的方法。
