Brandon W R, Boulos L M, Morse A
Louisiana State University Medical Center, Department of Medicine/Section of HIV, New Orleans 70112.
Int J STD AIDS. 1993 Mar-Apr;4(2):99-101. doi: 10.1177/095646249300400208.
A retrospective study of 767 HIV positive patients from a large urban public hospital, 238 of whom were co-infected with syphilis, was performed to determine the prevalence of neurosyphilis. A prevalence of 3% of neurosyphilis in the co-infected cohort was demonstrated. The 7 cases of neurosyphilis ascertained were of the early stage variety, with cranial nerve involvement the predominant focal deficit. Of the 5 cases presenting after initial diagnosis and treatment of syphilis, 4 were felt to be inadequately treated. An overall prevalence of 1% (7/767) was determined for the entire HIV(+) cohort. The majority of the cases of syphilis (90%) were characterized as latent syphilis. Based on these findings, the authors recommend routine CSF examination in all patients who are HIV positive and who present with latent syphilis. Treatment regimens should be maximized in an effort to reduce the prevalence of neurosyphilis in such a co-infected cohort.
对一家大型城市公立医院的767名HIV阳性患者进行了一项回顾性研究，其中238人同时感染了梅毒，以确定神经梅毒的患病率。结果显示，合并感染队列中神经梅毒的患病率为3%。确诊的7例神经梅毒均为早期，主要局灶性缺损为脑神经受累。在梅毒初次诊断和治疗后出现的5例病例中，有4例被认为治疗不充分。整个HIV阳性队列的总体患病率为1%（7/767）。大多数梅毒病例（90%）被归类为潜伏梅毒。基于这些发现，作者建议对所有HIV阳性且患有潜伏梅毒的患者进行常规脑脊液检查。应优化治疗方案，以降低此类合并感染队列中神经梅毒的患病率。
