Parnetti L, Abate G, Bartorelli L, Cucinotta D, Cuzzupoli M, Maggioni M, Villardita C, Senin U
Institute of Gerontology and Geriatrics, University of Perugia, Italy.
Drugs Aging. 1993 Mar-Apr;3(2):159-64. doi: 10.2165/00002512-199303020-00006.
A multicentre, randomised, controlled study compared the efficacy of l-alpha-glyceryl-phosphorylcholine (alpha GPC) and ST200 (acetyl-l-carnitine) among 126 patients with probable senile dementia of Alzheimer's type (SDAT) of mild to moderate degree. Efficacy was evaluated by means of behavioural scales and psychometric tests. The results showed significant improvements in most neuropsychological parameters in the alpha GPC recipients. Improvements also occurred in the ST200 recipients but to a lesser extent. Tolerability was good in both groups. These positive findings require replication in larger, double-blind, longitudinal studies coupling clinical and biological determinations.
一项多中心、随机、对照研究比较了126例轻度至中度可能的阿尔茨海默型老年性痴呆（SDAT）患者中l-α-甘油磷酸胆碱（α-GPC）和ST200（乙酰左旋肉碱）的疗效。通过行为量表和心理测量测试评估疗效。结果显示，接受α-GPC治疗的患者在大多数神经心理学参数上有显著改善。接受ST200治疗的患者也有改善，但程度较小。两组的耐受性都很好。这些阳性结果需要在结合临床和生物学测定的更大规模、双盲、纵向研究中进行重复验证。
