de Lencastre H, Figueiredo A M, Tomasz A
Rockefeller University, Laboratory of Microbiology, New York, New York.
Eur J Clin Microbiol Infect Dis. 1993;12 Suppl 1:S13-8. doi: 10.1007/BF02389872.
Cultures of heterogeneous strains of methicillin resistant Staphylococcus aureus are composed of several subpopulations of cells that differ in their level of antibiotic resistance and frequencies. Experimental evidence is presented indicating that the number of these subpopulations, their resistance level and the frequency with which they are represented in a culture are strain-specific and reproducible with a surprising degree of precision from one culture to another. This implies a genetic control of population structure in these bacteria.
耐甲氧西林金黄色葡萄球菌异质菌株的培养物由几个细胞亚群组成，这些亚群在抗生素耐药水平和频率上存在差异。实验证据表明，这些亚群的数量、它们的耐药水平以及它们在培养物中的出现频率具有菌株特异性，并且从一种培养物到另一种培养物都能以惊人的精度重现。这意味着这些细菌的群体结构存在遗传控制。
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