femA基因座失活的金黄色葡萄球菌菌株中肽聚糖亚单位组成的改变
Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus.
作者信息
de Jonge B L, Sidow T, Chang Y S, Labischinski H, Berger-Bachi B, Gage D A, Tomasz A
机构信息
Rockefeller University, New York, New York 10021.
出版信息
J Bacteriol. 1993 May;175(9):2779-82. doi: 10.1128/jb.175.9.2779-2782.1993.
Abstract
Tn551 inactivation of femA, a factor involved in methicillin resistance of Staphylococcus aureus, caused the production of peptidoglycan in which the fraction of monoglycyl- and serine-containing muropeptides was increased at the expense of pentaglycyl muropeptides. femA mutants have a specific block in the biosynthesis of pentaglycine cross bridges after the addition of the first glycine residue.
摘要
Tn551使金黄色葡萄球菌耐甲氧西林相关因子femA失活，导致肽聚糖生成，其中单甘氨酰和含丝氨酸的肽聚糖片段的比例增加，而五甘氨酰肽聚糖片段减少。femA突变体在添加第一个甘氨酸残基后，五肽甘氨酸交联桥的生物合成存在特定障碍。
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