Grekin R C, Shelton R M, Geisse J K, Frieden I
Department of Dermatologic Surgery, UCSF Medical Center 94143-0316.
J Dermatol Surg Oncol. 1993 Apr;19(4):380-7. doi: 10.1111/j.1524-4725.1993.tb00361.x.
Benign pigmented lesions are of a cosmetic concern to many individuals. Numerous treatments exist, including several types of lasers. The Candela 510 nm pigmented lesion dye laser has recently been added to this armamentarium. It is designed specifically for the treatment of superficial pigmented lesions while significantly decreasing the risk of scarring and prolonged hypopigmentation.
To describe the characteristics of the Candela pigmented lesion dye laser and report on the therapeutic outcome of patients treated for actinic lentigines, café-au-lait macules, melasma and red tattoos by one of the authors (RCG).
The Candela 510 nm pigmented lesion dye laser was used to treat solar lentigines, café-au-lait macules, melasma and red tattoo.
Excellent outcomes resulted on facial and hand lentigines (89% and 88% of patients had greater than 75% clearing, respectively), but often required more than one treatment. Lentigines located on the upper extremities and trunk improved less dramatically. Immediate greying occurred universally. Bruising was often noted. Treatment failures have been observed especially in treating lentigines located on the lower extremities. Café-au-lait macules responded inconsistently, with facial lesions giving the best results. Melasma responded poorly, often with hyperpigmentation. Three red tattoos cleared. Treatment failure may be related to inaccurate clinical assessment of pigment depth or regrowth of the lesion. Several cases are presented to demonstrate clinical and histologic effects of the laser.
The Candela 510-nm pigmented lesion dye laser is an effective treatment for superficial pigmented lesions. Its associated morbidity is minimal.
良性色素沉着病变是许多人关注的美容问题。现有多种治疗方法，包括几种类型的激光。坎德拉510纳米色素沉着病变染料激光最近已被纳入这一治疗手段。它专为治疗浅表色素沉着病变而设计，同时显著降低瘢痕形成和长期色素减退的风险。
描述坎德拉色素沉着病变染料激光的特点，并报告由作者之一（RCG）治疗的光化性雀斑样痣、咖啡牛奶斑、黄褐斑和红色纹身患者的治疗结果。
使用坎德拉510纳米色素沉着病变染料激光治疗日光性雀斑样痣、咖啡牛奶斑、黄褐斑和红色纹身。
面部和手部雀斑样痣治疗效果极佳（分别有89%和88%的患者色素清除率大于75%），但通常需要不止一次治疗。位于上肢和躯干的雀斑样痣改善程度较小。普遍出现即时变灰。常可见瘀斑。尤其在治疗下肢雀斑样痣时观察到治疗失败。咖啡牛奶斑反应不一，面部病变效果最佳。黄褐斑反应不佳，常出现色素沉着。3例红色纹身清除。治疗失败可能与色素深度的临床评估不准确或病变再生有关。展示了几例病例以说明激光的临床和组织学效果。
坎德拉510纳米色素沉着病变染料激光是治疗浅表色素沉着病变的有效方法。其相关的发病率极低。
