一种设计用于在生理预负荷下工作的新型骨骼肌动力心室（SMPV）

[A new skeletal muscle powered ventricle (SMPV) designed to work under physiologic preload].

作者信息

Oda T, Miyamoto A, Okamoto Y, Ban T

机构信息

Department of Cardiovascular Surgery, Kyoto University Faculty of Medicine, Japan.

出版信息

Nihon Kyobu Geka Gakkai Zasshi. 1993 Mar;41(3):356-62.

PMID:8478562

Abstract

To maximize pumping function the SMPV has been highly preloaded (over 30 mmHg); but the effects of pump size and configuration on the required preload have never been determined. A new double barrel dual chamber single layered (DCSL) SMPV having two SL small pumps in parallel was compared with a single chamber double layered small pump (SCDL). Stroke volume (SV) and stroke work (SW) were determined in acutely constructed SMPV using mongrel dog untrained latissimus dorsi: 10 DCSL and 12 SCDL. Under physiologic afterload (120 mmHg) and preload (15 mmHg), the DCSL displayed a significantly (p < 0.05) larger SV (9.9 +/- 1.2 ml) and SW (0.84 +/- 0.15 x 10(6) ergs) than the SCDL pumps (SV = 6.9 +/- 0.6 ml, and SW = 0.55 +/- 0.07 x 10(6) ergs). The DCSL pumps, requiring less muscle mass for its construction, indicated better performance under physiologic pre and afterload conditions than SCDL pumps.

摘要

为使泵功能最大化，已对串联膜式心室辅助泵（SMPV）进行了高度预负荷（超过30 mmHg）；但泵的尺寸和结构对所需预负荷的影响尚未确定。将一种新型双腔双层单室（DCSL）SMPV（有两个并联的单层小泵）与单腔双层小泵（SCDL）进行比较。使用杂种狗未经训练的背阔肌在急性构建的SMPV中测定每搏输出量（SV）和每搏功（SW）：10个DCSL和12个SCDL。在生理后负荷（120 mmHg）和预负荷（15 mmHg）下，DCSL的SV（9.9±1.2 ml）和SW（0.84±0.15×10⁶尔格）显著（p<0.05）大于SCDL泵（SV = 6.9±0.6 ml，SW = 0.55±0.07×10⁶尔格）。DCSL泵构建所需的肌肉量较少，表明在生理预负荷和后负荷条件下其性能优于SCDL泵。