Rizzi R, Re F, Bianchi A, De Feo V, de Simone F, Bianchi L, Stivala L A
Departmento di Farmacologia, Chemioterapia e Tossicologia Medica, Università degli Studi di Milano, Italy.
J Ethnopharmacol. 1993 Jan;38(1):63-77. doi: 10.1016/0378-8741(93)90080-o.
Mutagenic and antimutagenic activities of extracts and chromatographic fractions of Uncaria tomentosa bark are reported. The plant extracts and fractions show no mutagenic effect in different strains of Salmonella typhimurium with and without metabolic activation. However, the plant extracts and fractions show a protective antimutagenic effect in vitro against photomutagenesis induced by 8-methoxy-psoralen (8-MOP) plus UVA in S. typhimurium TA 102. A decoction of U. tomentosa ingested daily for 15 days by a smoker decreased the mutagenicity induced in S. typhimurium TA98 and TA100 by the subject's urine.
据报道，钩藤树皮提取物及色谱分离组分具有诱变和抗诱变活性。在有或无代谢活化的情况下，该植物提取物及组分对不同菌株的鼠伤寒沙门氏菌均无诱变作用。然而，该植物提取物及组分在体外对8-甲氧基补骨脂素（8-MOP）加紫外线A诱导的鼠伤寒沙门氏菌TA 102光诱变具有保护性抗诱变作用。一名吸烟者连续15天每日饮用钩藤水煎剂后，其尿液对鼠伤寒沙门氏菌TA98和TA100的诱变性降低。
