Lefebvre P P, Malgrange B, Staecker H, Moonen G, Van de Water T R
Department of Human Physiology and Pathophysiology, University of Liège, Belgium.
Science. 1993 Apr 30;260(5108):692-5. doi: 10.1126/science.8480180.
Sensorineural hearing loss resulting from the loss of auditory hair cells is thought to be irreversible in mammals. This study provides evidence that retinoic acid can stimulate the regeneration in vitro of mammalian auditory hair cells in ototoxic-poisoned organ of Corti explants in the rat. In contrast, treatment with retinoic acid does not stimulate the formation of extra hair cells in control cultures of Corti's organ. Retinoic acid-stimulated hair cell regeneration can be blocked by cytosine arabinoside, which suggests that a period of mitosis is required for the regeneration of auditory hair cells in this system. These results provide hope for a recovery of hearing function in mammals after auditory hair cell damage.
因听觉毛细胞缺失导致的感音神经性听力损失在哺乳动物中被认为是不可逆的。本研究提供了证据表明，视黄酸能够刺激大鼠耳毒性中毒的柯蒂氏器外植体中哺乳动物听觉毛细胞的体外再生。相比之下，视黄酸处理并不会刺激柯蒂氏器对照培养物中额外毛细胞的形成。视黄酸刺激的毛细胞再生可被阿糖胞苷阻断，这表明该系统中听觉毛细胞的再生需要一段有丝分裂期。这些结果为哺乳动物听觉毛细胞损伤后听力功能的恢复带来了希望。
