Peters K M, Zwadlo-Klarwasser G, Koberg K, Rosendahl T, Zilkens K W, Schmutzler W
Orthopädische Klinik, RWTH Aachen.
Z Orthop Ihre Grenzgeb. 1993 Jan-Feb;131(1):37-41. doi: 10.1055/s-2008-1039902.
Similar to other chronic inflammatory diseases such as rheumatoid arthritis the distribution of macrophage subtypes seems to be disturbed in post-traumatic osteomyelitis. This atypical distribution is clearly locally restricted in osteomyelitis. 27E10-positive macrophages found only during the acute phase of inflammation were reduced in 39%, the 25F9-positive subtype, predominating in the late stage of inflammation, was missing in 33%. The antiinflammatory macrophage RM3/1 was decreased in 40% of the osteomyelitis biopsies. Local suppression of macrophage subsets has to be discussed as one of the reasons for the persistence of chronic inflammatory processes in osteomyelitis.
与类风湿关节炎等其他慢性炎症性疾病相似，巨噬细胞亚型的分布在创伤后骨髓炎中似乎受到干扰。这种非典型分布在骨髓炎中明显局限于局部。仅在炎症急性期发现的27E10阳性巨噬细胞减少了39%，在炎症后期占主导地位的25F9阳性亚型有33%缺失。抗炎巨噬细胞RM3/1在40%的骨髓炎活检组织中减少。巨噬细胞亚群的局部抑制必须被视为骨髓炎中慢性炎症过程持续存在的原因之一。
