Paukov V S, Gortishchev V K, Ermakova N G, Shkrob L O, Shalchkova L P
Arkh Patol. 1996 Jan-Feb;58(1):28-33.
Biopsies from 40 patients with chronic trophic ulcers of lower limbs or osteomyelitis were investigated. Combination of immunopathological processes in the form of immune deficiency, unbalance of T-lymphocyte subpopulations and immunoglobulins, increased levels of circulating immunocomplexes and T-active lymphocytes, high functional T-lymphocyte activity. Moreover, there is a decrease of both chemotaxis and spontaneous motility of neutrophil leukocytes and phagocytosis. The disturbance of cellular and humoral immunologic reactions and nonspecific resistance correlates with morphological features of ulcers: suppression of collagenogenesis, productive vasculitis, obliteration and reduction of vessels, plasmatization of granulation tissue. The causes and mechanisms of the changes observed resulting in the chronic inflammation which takes the form of vitium cordis are discussed.
对40例下肢慢性营养性溃疡或骨髓炎患者的活检组织进行了研究。免疫病理过程表现为免疫缺陷、T淋巴细胞亚群和免疫球蛋白失衡、循环免疫复合物和T活性淋巴细胞水平升高、T淋巴细胞功能活性增强。此外，中性粒细胞的趋化性和自发运动性以及吞噬作用均降低。细胞和体液免疫反应及非特异性抵抗力的紊乱与溃疡的形态学特征相关：胶原生成受抑制、增殖性血管炎、血管闭塞和减少、肉芽组织的浆细胞化。本文讨论了所观察到的导致以心脏缺陷形式出现的慢性炎症的变化的原因和机制。
