Tjønneland A, Overvad K, Thorling E, Ewertz M
Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Am J Clin Nutr. 1993 May;57(5):629-33. doi: 10.1093/ajcn/57.5.629.
Adipose tissue fatty acids, it has been proposed, reflect dietary intake. Using data from a validation study preceding a prospective study on diet, cancer, and health in Denmark, we were able to compare fatty acid profiles in adipose tissue biopsies from 86 individuals (23 men and 63 women) aged 40-64 y and dietary intake of fatty acids (as percentage of total fat) assessed by two 7-d weighed-diet records or by a semi-quantitative food frequency questionnaire. Correlation coefficients (Pearson r) between fatty acid concentrations in adipose tissue biopsies (as percentage of total peak area) and dietary intake of fatty acid (percentage of total fat), determined from the diet records for men and women, respectively, were as follows: polyunsaturated fatty acids r = 0.74 and r = 0.46; n - 3 fatty acids of marine origin: eicosapentaenoic acid r = 0.15 and r = 0.61, and docosahexaenoic acid r = 0.47 and r = 0.57. Correlation coefficients obtained by using the food frequency questionnaire were slightly lower for most fatty acids.
有人提出，脂肪组织中的脂肪酸反映了饮食摄入量。利用丹麦一项关于饮食、癌症和健康的前瞻性研究之前的一项验证研究的数据，我们能够比较86名年龄在40 - 64岁的个体（23名男性和63名女性）的脂肪组织活检样本中的脂肪酸谱，以及通过两份7天称重饮食记录或半定量食物频率问卷评估的脂肪酸饮食摄入量（占总脂肪的百分比）。分别根据男性和女性的饮食记录确定的脂肪组织活检样本中脂肪酸浓度（占总峰面积的百分比）与脂肪酸饮食摄入量（占总脂肪的百分比）之间的相关系数（Pearson r）如下：多不饱和脂肪酸r = 0.74和r = 0.46；海洋来源的n - 3脂肪酸：二十碳五烯酸r = 0.15和r = 0.61，以及二十二碳六烯酸r = 0.47和r = 0.57。使用食物频率问卷获得的相关系数对于大多数脂肪酸来说略低。
