Pardo J V, Pardo P J, Raichle M E
Department of Psychiatry, Washington University Medical Center, St. Louis.
Am J Psychiatry. 1993 May;150(5):713-9. doi: 10.1176/ajp.150.5.713.
The authors explored the question of whether acute, transient changes in mood are reflected in activation of discrete neuronal systems in the human brain.
Using positron emission tomography, they measured the regional cerebral blood flow (CBF) of seven psychiatrically healthy subjects under two conditions. During the control condition the subjects were resting with their eyes closed. During the active condition, with their eyes still closed, they were asked to imagine or recall a situation that would make them feel very sad. They were explicitly asked to experience sadness and to avoid any feelings of anger or anxiety.
There were significant differences in regional CBF measured during the control condition and during the active condition, particularly in the inferior and orbitofrontal cortices. Women showed bilateral inferior and orbitofrontal activation, but men displayed predominantly left-sided activation in these areas.
The authors conclude that the inferior and orbitofrontal cortices play an important role in normal emotional cognitive processes.
作者探讨了情绪的急性、短暂变化是否反映在人类大脑中离散神经元系统的激活上这一问题。
他们使用正电子发射断层扫描技术，在两种情况下测量了7名精神健康受试者的局部脑血流量（CBF）。在对照情况下，受试者闭眼休息。在活跃情况下，他们仍闭眼，被要求想象或回忆一个会让他们感到非常悲伤的情境。明确要求他们体验悲伤并避免任何愤怒或焦虑情绪。
对照情况和活跃情况期间测量的局部脑血流量存在显著差异，特别是在眶额下回皮质。女性表现出双侧眶额下回激活，但男性在这些区域主要表现为左侧激活。
作者得出结论，眶额下回皮质在正常情绪认知过程中起重要作用。
