Pozio E, Varese P, Morales M A, Croppo G P, Pelliccia D, Bruschi F
Istituto Superiore di Sanita, Rome, Italy.
Am J Trop Med Hyg. 1993 Apr;48(4):568-75. doi: 10.4269/ajtmh.1993.48.568.
The first documented report of an outbreak of human trichinellosis caused by Trichinella spiralis in Italy is described. Two family groups were involved. The source was wild boar meat products. The principal clinical features were fever (60%), myalgia (50%), and diarrhea (40%). The most useful laboratory indicators were eosinophilia (100%), elevated levels of creatine phosphokinase (CPK) (90%) and other muscle enzymes, parasite-specific IgG titers (100%), and anti-newborn larvae antibodies (30%). The levels of these responses correlated with the number of infective muscle larvae ingested, which was influenced by the length of time the ingested meat was cured. The clinical and biological features observed during human infection with T. spiralis appear to have been different from those reported during two outbreaks due to T. britovi, which occurred in southern Italy. The main distinctions between the two types of infections were a longer duration of parasite-specific IgG, increased CPK levels, and a more severe intestinal symptomatology in T. spiralis-infected patients than in those infected with T. britovi.
本文描述了意大利首次有记录的由旋毛虫引起的人旋毛虫病暴发。涉及两个家庭群体。传染源是野猪肉制品。主要临床特征为发热（60%）、肌痛（50%）和腹泻（40%）。最有用的实验室指标为嗜酸性粒细胞增多（100%）、肌酸磷酸激酶（CPK）水平升高（90%）及其他肌肉酶、寄生虫特异性IgG滴度（100%）和抗新生幼虫抗体（30%）。这些反应的水平与摄入的感染性肌幼虫数量相关，而感染性肌幼虫数量受所摄入肉类腌制时间长短的影响。在人体感染旋毛虫期间观察到的临床和生物学特征似乎与意大利南部发生的两次由布氏旋毛虫引起的暴发中所报告的不同。两种感染类型之间的主要区别在于，旋毛虫感染患者的寄生虫特异性IgG持续时间更长、CPK水平升高，且肠道症状比布氏旋毛虫感染患者更严重。
