Paty D W
University of British Columbia, Vancouver, Canada.
Curr Opin Neurol Neurosurg. 1993 Apr;6(2):202-8.
Magnetic resonance and various chemical measurements, such as spectroscopy, are being systematically applied to both multiple sclerosis and the experimental model (experimental allergic encephalitis). The dynamic aspects of multiple sclerosis pathology can be visualized on serial magnetic resonance imaging scans, and enhancement techniques help distinguish another type of activity by showing a leaky blood-brain barrier in acute lesions. Quantitative measures applied to the image also appear to provide an index of the burden of disease both in individual patients and in groups. A combination of the dynamic information available from serial studies and the quantitative information concerning burden of disease promises to provide both sensitivity and objectivity to standard outcome measures in multiple sclerosis. In addition, natural history studies of the evolution of magnetic resonance imaging and spectroscopy will revolutionize our understanding of the evolution of the actual tissue changes in multiple sclerosis pathology that can be characterized during life.
磁共振成像以及各种化学测量方法，如光谱学，正被系统地应用于多发性硬化症和实验模型（实验性变应性脑脊髓炎）。多发性硬化症病理学的动态方面可以通过连续的磁共振成像扫描直观呈现，增强技术通过显示急性病变中血脑屏障渗漏来帮助区分另一种活动类型。应用于图像的定量测量似乎也能为个体患者和群体中的疾病负担提供一个指标。来自系列研究的动态信息与有关疾病负担的定量信息相结合，有望为多发性硬化症的标准结局测量提供敏感性和客观性。此外，对磁共振成像和光谱学演变的自然史研究将彻底改变我们对多发性硬化症病理学中实际组织变化演变的理解，这些变化在生命过程中是可以被表征的。
