Rosenberg-Schaffer L J, Lucas J H
Department of Biological Sciences, University of North Texas, Denton 76203-5218.
Brain Res. 1993 Mar 12;605(2):327-31. doi: 10.1016/0006-8993(93)91760-p.
Cultured spinal neurons were subjected to dendrite amputation 100 microns from the perikaryon and treated with methylprednisolone (MP). Survival was significantly increased by 30 micrograms/ml MP but not by 10, 20 or 60 micrograms/ml. Survival was reduced by 100 micrograms/ml MP. These results suggest: (1) MP protects neurons subjected to physical trauma, and (2) the effective dose range is very narrow. These findings may have implications for MP's observed bimodal effects in spinal cord injury.
