小牛轮状病毒中型特异性抗原的定位
Location of type-specific antigens in calf rotaviruses.
作者信息
Bridger J C
出版信息
J Clin Microbiol. 1978 Dec;8(6):625-8. doi: 10.1128/jcm.8.6.625-628.1978.
Abstract
Rotavirus antisera with and without neutralizing activity to calf rotavirus were compared for their ability to agglutinate calf rotavirus particles with and without an outer capsid layer. Particles without the outer capsid layer were agglutinated by antisera with immunofluorescent antibody activity and by antisera with immunofluorescent antibody and neutralizing activity. Particles with the outer capsid layer were agglutinated only by antisera with neutralizing activity. The neutralization test appears to be type specific, and it was concluded that type-specific antigens are associated with the outer capsid layer of rotaviruses. Since particles with the outer capsid layer were not agglutinated by antisera lacking neutralizing activity but possessing immunofluorescent antibody activity, it was concluded that in intact particles the group-specific antigen is masked by the outer capsid layer.
摘要
对具有和不具有中和小牛轮状病毒活性的轮状病毒抗血清，比较它们凝集有和没有外衣壳层的小牛轮状病毒颗粒的能力。没有外衣壳层的颗粒可被具有免疫荧光抗体活性的抗血清以及具有免疫荧光抗体和中和活性的抗血清凝集。具有外衣壳层的颗粒仅被具有中和活性的抗血清凝集。中和试验似乎具有型特异性，得出的结论是型特异性抗原与轮状病毒的外衣壳层相关。由于具有外衣壳层的颗粒不能被缺乏中和活性但具有免疫荧光抗体活性的抗血清凝集，因此得出结论，在完整颗粒中，群特异性抗原被外衣壳层掩盖。
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