系统性红斑狼疮在不同犹太裔以色列族群中的表现。
Expression of systemic lupus erythematosus in various ethnic Jewish Israeli groups.
作者信息
Wysenbeek A J, Leibovici L, Weinberger A, Guedj D
机构信息
Rheumatology Unit, Beilinson Medical Center, Petah Tiqva, Israel.
出版信息
Ann Rheum Dis. 1993 Apr;52(4):268-71. doi: 10.1136/ard.52.4.268.
OBJECTIVES
To assess the expression of systemic lupus erythematosus (SLE) in Jewish Israeli patients according to ethnic origin.
METHODS
Eighty four patients with SLE were divided into groups according to origin and compared for history, physical examination, and laboratory variables.
RESULTS
Patients of Sephardic origin had more serious disease manifestations than Ashkenazi patients in 60 of the 76 variables examined. They had significantly worse muscle pain, alopecia, and cutaneous vasculitis, higher antibodies to DNA and erythrocyte sedimentation rate, and significantly lower complement and leucocytes. Sephardic patients were divided into subgroups according to country: Mediterranean area, Iran-Iraq-India, and Yemen. All three subgroups had more serious disease manifestations than the Ashkenazi group, and the Yemenite patients had the most serious manifestations among the Sephardic subgroups. The Sephardic patients had a significantly lower education level, but only origin, and not education level or age, was significantly related to disease manifestations on multivariate analysis.
CONCLUSION
More serious manifestations of SLE are found among Jewish patients of Sephardic origin, but these are not related to level of education or age.
目的
根据种族起源评估以色列犹太患者系统性红斑狼疮（SLE）的表达情况。
方法
84例SLE患者按起源分组，比较其病史、体格检查及实验室指标。
结果
在76项检查变量中的60项中，西班牙裔起源的患者比德系犹太人患者有更严重的疾病表现。他们的肌肉疼痛、脱发和皮肤血管炎明显更严重，抗DNA抗体和红细胞沉降率更高，补体和白细胞明显更低。西班牙裔患者根据国家分为亚组：地中海地区、伊朗 - 伊拉克 - 印度和也门。所有三个亚组的疾病表现都比德系犹太人组更严重，也门裔患者在西班牙裔亚组中表现最为严重。西班牙裔患者的教育水平明显较低，但在多变量分析中，只有起源与疾病表现显著相关，而教育水平或年龄则不然。
结论
在西班牙裔起源的犹太患者中发现SLE有更严重的表现，但这些与教育水平或年龄无关。
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