Brown S E, Allen H H, Robins R N
Am J Obstet Gynecol. 1977 Apr 1;127(7):713-7. doi: 10.1016/0002-9378(77)90244-7.
Delayed primary wound closure was performed in 146 patients considered at risk of developing wound infection according to established criteria. These patients were matched individually for age, weight, diagnosis, and the use of prophylactic antibiotics with 146 patients undergoing immediate wound closure during the same time period. The matched pairs were subdivided into five categories depending on the indication for delayed closure; obesity, cancer, "above and below" procedure, infection, and opened bowel. In all categories the incidence of wound infection was significantly lower in the patients with delayed closure. The over-all infection rate was reduced from 23.3% in the control group to 2.1% in the study group. Hospital stay was unaffected. Delayed primary wound closure provides a safe, simple, effective means of reducing the incidence of wound infection.
根据既定标准，对146例被认为有伤口感染风险的患者进行了延迟一期伤口缝合。这些患者在年龄、体重、诊断以及预防性抗生素使用方面与同期146例接受即时伤口缝合的患者进行了个体匹配。根据延迟缝合的指征，匹配对被细分为五类：肥胖、癌症、“上下”手术、感染和肠道开放。在所有类别中，延迟缝合患者的伤口感染发生率均显著较低。总体感染率从对照组的23.3%降至研究组的2.1%。住院时间未受影响。延迟一期伤口缝合为降低伤口感染发生率提供了一种安全、简单、有效的方法。
