An Med Interna. 1993 Mar;10(3):119-22.
The response to the therapy with captopril administered in one daily dose (between 25 and 100 mg) to a group of 468 old patients with arterial hypertension has been studied. In 87% of the cases, normalization of the arterial pressure was achieved at six months (values lower than 160/95 mmHg). The therapy resulted in a progressive reduction during the follow-up period, with a significant initial reduction (p < 0.001). Just 7.5% of the patients needed the administration of diuretics in addition to the therapy. Just nine patients had to discontinue the follow-up due to side effects (dry cough in 4; gastrointestinal disorders in 4; postural hypertension in 1 case). We conclude that captopril administered in one daily dose is a safe and effective therapy for the treatment of mild to moderate arterial hypertension among the elderly.
对一组468例老年高血压患者使用卡托普利进行每日一次剂量（25至100毫克）治疗的反应进行了研究。87%的病例在六个月时实现了血压正常化（血压值低于160/95毫米汞柱）。在随访期间，治疗导致血压逐渐降低，初始时显著降低（p < 0.001）。仅7.5%的患者在治疗之外还需要使用利尿剂。仅9例患者因副作用而不得不中断随访（4例干咳；4例胃肠道紊乱；1例体位性高血压）。我们得出结论，每日一次剂量的卡托普利是治疗老年轻度至中度高血压的一种安全有效的疗法。
