Sadeg N, Pham Huy C, Martin C, Warnet J M, Claude J R
Laboratoire de Toxicologie, Faculté de Pharmacie, Paris.
Drug Chem Toxicol. 1993;16(2):165-74. doi: 10.3109/01480549309031994.
Rabbit renal microsomes were used to investigate the effect on lipid peroxidation (LPO) of cyclosporin A (CsA) and its first generation metabolites M1, M17 and M21, and of two natural CsA analogs: cyclosporins C and D (CsC & CsD respectively), at concentrations of 1 to 10 micrograms/ml. No induction of lipid peroxidation was observed with these substances except CsA at a high level (10 microgram/ml); but at a concentration of CsA that would be reached in vivo, no inductive effect on LPO was noted. A moderate inhibitory effect upon LPO was observed with CsC and M21, but its biological significance is questionable.
采用兔肾微粒体研究了环孢素A（CsA）及其第一代代谢产物M1、M17和M21，以及两种天然CsA类似物：环孢素C和D（分别为CsC和CsD）在浓度为1至10微克/毫升时对脂质过氧化（LPO）的影响。除高浓度（10微克/毫升）的CsA外，未观察到这些物质诱导脂质过氧化；但在体内可能达到的CsA浓度下，未发现对LPO有诱导作用。CsC和M21对LPO有中度抑制作用，但其生物学意义尚不确定。
