Goran M I, Beer W H, Wolfe R R, Poehlman E T, Young V R
Metabolism Unit, Shriners Burns Institute, Galveston, TX.
Metabolism. 1993 Apr;42(4):487-96. doi: 10.1016/0026-0495(93)90108-z.
Interindividual and intraindividual variation in total energy expenditure (TEE) were examined in 17 healthy, free-living men (weight, 56.4 to 82.4 kg; age, 18 to 30 years). TEE over 14 days, resting metabolic rate (RMR), and body composition were measured two or three times during 77 days of fixed caloric intake using doubly labeled water, respiratory gas analysis, and isotope dilution, respectively. When individual data were averaged, TEE was most significantly related to fat-free mass ([FFM] r = .73, P = .001), body mass (r = .70, P = .002), and RMR (r = .63, P = .006). After adjusting TEE for BM, a significant inverse relation with age was found (partial r = -.52, P = .032). Stepwise regression analysis showed that 69% of individual variation in TEE was explained by BM, age, and fasting respiratory exchange ratio (RER). TEE/RMR averaged 1.73 +/- 0.25 (range, 1.38 to 2.32), and was independent of age and body composition. In 10 subjects in whom triplicate observations of TEE were performed, the average experimental variation for TEE was +/- 11.9% (range, 6.1% to 19.6%) compared with a theoretical estimate of precision of +/- 5.9% based on the reported isotope dose and analytical uncertainty. The difference between theoretical estimates of precision and observed experimental variation suggests that inherent random variation in free-living TEE is +/- 10% (ie, square root of 12(2)-6(2)) in subjects maintained on fixed caloric intake. We conclude that in young free living men (1) BM, age, and RER are important determinants of TEE; and (2) intraindividual variation in TEE is approximately +/- 10% due to fluctuations in physical activity levels within individuals over time.
在17名健康、自由生活的男性（体重56.4至82.4千克；年龄18至30岁）中，研究了个体间和个体内总能量消耗（TEE）的差异。在77天固定热量摄入期间，分别使用双标水、呼吸气体分析和同位素稀释法，对TEE进行了14天的测量，对静息代谢率（RMR）和身体成分进行了两到三次测量。将个体数据平均后，TEE与去脂体重（[FFM] r = 0.73，P = 0.001）、体重（r = 0.70，P = 0.002）和RMR（r = 0.63，P = 0.006）的相关性最为显著。在根据体重调整TEE后，发现与年龄呈显著负相关（偏r = -0.52，P = 0.032）。逐步回归分析表明，TEE的个体差异中有69%可由体重、年龄和空腹呼吸交换率（RER）来解释。TEE/RMR的平均值为1.73±0.25（范围为1.38至2.32），且与年龄和身体成分无关。在对10名受试者进行了三次TEE观测的研究中，TEE的平均实验变异为±11.9%（范围为6.1%至19.6%），而根据报告的同位素剂量和分析不确定性得出的理论精度估计值为±5.9%。理论精度估计值与观察到的实验变异之间的差异表明，在固定热量摄入的受试者中，自由生活状态下TEE的固有随机变异为±10%（即12²-6²的平方根）。我们得出结论，在年轻的自由生活男性中：（1）体重、年龄和RER是TEE的重要决定因素；（2）由于个体随时间身体活动水平的波动，TEE的个体内变异约为±10%。
