Callahan M J, Kinsora J J, Harbaugh R E, Reeder T M, Davis R E
Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105.
Neurobiol Aging. 1993 Mar-Apr;14(2):147-51. doi: 10.1016/0197-4580(93)90090-x.
Systemic administration of anticholinergic agents impairs cognitive performance in animals and man. The anticholinergic, scopolamine, has profound effects on peripheral and central cholinergic function, making interpretation of its effects on cognitive performance difficult. To circumvent this problem, scopolamine was administered directly to the central nervous system of rhesus monkeys using a subcutaneously implanted infusion pump connected to a cannulae directed toward the right lateral ventricle. Intracerebroventricular (ICV) infusion of scopolamine (0.004, 0.012, 12.5, and 40.0 micrograms/kg/h) produced a dose-dependent decrease in the number of responses on a continuous performance task. Response decrements produced by scopolamine were seen mainly during the last half of the test session and at short stimulus durations. These data suggest that scopolamine produces a deficit in sustained attention or slowing of information processing that is mediated through direct central cholinergic blockade in the rhesus monkey.
抗胆碱能药物的全身给药会损害动物和人类的认知表现。抗胆碱能药物东莨菪碱对周围和中枢胆碱能功能有深远影响，这使得对其对认知表现的影响进行解释变得困难。为了规避这个问题，使用连接到指向右侧脑室的套管的皮下植入式输液泵，将东莨菪碱直接施用于恒河猴的中枢神经系统。脑室内（ICV）注入东莨菪碱（0.004、0.012、12.5和40.0微克/千克/小时）会使连续执行任务中的反应次数呈剂量依赖性减少。东莨菪碱产生的反应减少主要出现在测试时段的后半段以及短刺激持续时间时。这些数据表明，东莨菪碱通过对恒河猴中枢胆碱能的直接阻断，导致持续注意力缺陷或信息处理速度减慢。
