Aigner T G, Mishkin M
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892.
Behav Brain Res. 1993 Apr 30;54(2):133-6. doi: 10.1016/0166-4328(93)90071-w.
Performance of three rhesus monkeys on a test of one-trial stimulus-reward association, in which recall intervals ranged from 0.5 to 6.5 min, was evaluated during nondrug-control conditions and following administration of the muscarinic-receptor blocker scopolamine. During control sessions, performance averaged 78% correct responses. Following administration of 10.0 and 17.8 micrograms/kg of scopolamine, performance fell significantly, to 69% and 63% correct responses, respectively. This dose-dependent impairment in recall was similar to the impairment we reported previously in recognition. Although the results thus failed to support a suggestion derived from behavioral electrophysiological findings that stimulus-reward association might be more vulnerable to scopolamine than stimulus recognition, they provide additional evidence for a cholinergic contribution to cognitive memory.
在非药物对照条件下以及给予毒蕈碱受体阻滞剂东莨菪碱后，对三只恒河猴在一次试验刺激-奖励关联测试中的表现进行了评估，其中回忆间隔时间为0.5至6.5分钟。在对照试验期间，表现平均为78%的正确反应。给予10.0微克/千克和17.8微克/千克的东莨菪碱后，表现显著下降，分别降至69%和63%的正确反应。这种回忆中剂量依赖性损伤类似于我们之前报道的识别方面的损伤。虽然结果未能支持从行为电生理学研究结果得出的一个观点，即刺激-奖励关联可能比刺激识别更容易受到东莨菪碱的影响，但它们为胆碱能对认知记忆的贡献提供了额外证据。
