Kinosada Y, Ono M, Okuda Y, Seta H, Hada Y, Hattori T, Nomura Y, Sakuma H, Takeda K, Ishii Y
Department of Radiology, School of Medicine, Mie University.
Nihon Igaku Hoshasen Gakkai Zasshi. 1993 Feb 25;53(2):171-9.
We developed a new noninvasive technique to visualize the anatomical structure of the nerve fiber system in vivo, and named this technique magnetic resonance (MR) tractography and the acquired image an MR tractogram. MR tractography has two steps. One is to obtain diffusion-weighted images sensitized along axes appropriate for depicting the intended nerve fibers with anisotropic water diffusion MR imaging. The other is to extract the anatomical structure of the nerve fiber system from a series of diffusion-weighted images by the maximum intensity projection method. To examine the clinical usefulness of the proposed technique, many contiguous, thin (3 mm) coronal two-dimensional sections of the brain were acquired sequentially in normal volunteers and selected patients with paralyses, on a 1.5 Tesla MR system (Signa, GE) with an ECG-gated Stejskal-Tanner pulse sequence. The structure of the nerve fiber system of normal volunteers was almost the same as the anatomy. The tractograms of patients with paralyses clearly showed the degeneration of nerve fibers and were correlated with clinical symptoms. MR tractography showed great promise for the study of neuroanatomy and neuroradiology.
我们开发了一种新的无创技术，用于在体内可视化神经纤维系统的解剖结构，并将该技术命名为磁共振（MR）纤维束成像，所获取的图像称为MR纤维束图。MR纤维束成像有两个步骤。一是通过各向异性水扩散磁共振成像，获取沿适合描绘目标神经纤维的轴方向敏感的扩散加权图像。另一个是通过最大强度投影法从一系列扩散加权图像中提取神经纤维系统的解剖结构。为了检验该技术的临床实用性，在1.5特斯拉MR系统（Signa，GE）上，使用心电图门控的斯泰斯卡尔-坦纳脉冲序列，对正常志愿者和选定的瘫痪患者依次采集了许多连续的、薄的（3毫米）冠状二维脑部切片。正常志愿者的神经纤维系统结构与解剖结构几乎相同。瘫痪患者的纤维束图清楚地显示了神经纤维的退化，并且与临床症状相关。MR纤维束成像在神经解剖学和神经放射学研究方面显示出巨大的前景。
