The role of lipid peroxidation and calcium in galactosamine induced toxicity in the rat liver.
作者信息
Seçkin S, Koçak-Toker N, Uysal M, Oz B
机构信息
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
出版信息
Res Commun Chem Pathol Pharmacol. 1993 Apr;80(1):117-20.
PMID:8488337
Abstract
Liver homogenate and subcellular fractional levels of lipid peroxides, homogenate glutathione (GSH) and calcium contents and hepatic plasma membrane Ca(2+)-ATPase activity were determined in rats, 12, 18, 24 and 48 hours after treatment with a single dose of 1 g/kg galactosamine. Lipid peroxides and calcium levels in liver homogenate and subcellular fractions were found to increase, but hepatic GSH content and Ca(2+)-ATPase activity were observed to decrease reversibly.
摘要
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