Artigas J, Grosse G, Niedobitek F
Institute of Pathology, Auguste-Viktoria-Krankenhaus, Berlin, Germany.
Arch Pathol Lab Med. 1993 May;117(5):540-1.
Cerebral toxoplasmosis is the most common cause of focal brain disease in patients with the acquired immunodeficiency syndrome. A 24-year-old human immunodeficiency virus-infected woman with two previous episodes of Pneumocystis carinii pneumonia presented with diarrhea and fever. Despite antibiotic treatment, septic shock developed, and she died 3 weeks after the symptoms began. Histologic and histochemical studies revealed an anergic toxoplasmosis with dissemination in all examined organs. There were multiple foci of toxoplasmic cysts and free tachyzoites, sometimes with minute areas of necrosis, but no inflammatory reaction at all. Since effective treatment of toxoplasmosis is available, the occurrence of this rare form of toxoplasmosis should be kept in mind.
脑弓形虫病是获得性免疫缺陷综合征患者局灶性脑疾病最常见的病因。一名24岁感染人类免疫缺陷病毒的女性，既往有两次卡氏肺孢子虫肺炎发作史，此次出现腹泻和发热。尽管进行了抗生素治疗，但仍发生了感染性休克，症状出现3周后死亡。组织学和组织化学研究显示为无反应性弓形虫病，病变播散至所有检查的器官。有多个弓形虫囊肿病灶和游离速殖子，有时伴有微小坏死区域，但完全没有炎症反应。由于有有效的弓形虫病治疗方法，应牢记这种罕见形式的弓形虫病的发生。
