Weinreb R N, Lusky M, Bartsch D U, Morsman D
Department of Ophthalmology, University of California, San Diego.
Arch Ophthalmol. 1993 May;111(5):636-8. doi: 10.1001/archopht.1993.01090050070031.
A confocal scanning diode laser ophthalmoscope was used to determine the number of examinations needed to obtain highly reproducible topographic measurements of the optic nerve head and peripapillary retina.
Topographic images of the optic nerve head and peripapillary retina were obtained in one randomly selected eye on five separate visits. On each occasion the selected eye had five examinations. For each examination, one image was acquired (a total of 25 images per eye). Reproducibility was calculated as the average SD of all image elements (65,536 pixels).
Glaucoma referral center.
Five normal subjects and five patients with glaucoma.
Topographic imaging of the optic nerve head and peripapillary retina.
Number of examinations needed to obtain highly reproducible topographic measurements.
In healthy subjects, reproducibility with one examination per visit was 35.5 microns; this improved to 25.7 microns with three examinations and 22.5 microns with five examinations. In older patients with glaucoma, the reproducibility improved from 40.2 microns with one examination per visit to 28.5 and 24.1 microns with three and five examinations, respectively.
We recommend a series of three examinations to provide high reproducibility with optimal efficiency in terms of time and materials used.
使用共焦扫描二极管激光检眼镜来确定获得高度可重复的视神经乳头和视乳头周围视网膜地形图测量所需的检查次数。
在五次单独就诊时，对一只随机选择的眼睛获取视神经乳头和视乳头周围视网膜的地形图图像。每次就诊时，选定的眼睛进行五次检查。每次检查获取一张图像（每只眼睛共25张图像）。重复性计算为所有图像元素（65,536像素）的平均标准差。
青光眼转诊中心。
五名正常受试者和五名青光眼患者。
对视神经乳头和视乳头周围视网膜进行地形图成像。
获得高度可重复的地形图测量所需的检查次数。
在健康受试者中，每次就诊进行一次检查时的重复性为35.5微米；进行三次检查时提高到25.7微米，进行五次检查时为22.5微米。在老年青光眼患者中，重复性从每次就诊进行一次检查时的40.2微米分别提高到进行三次和五次检查时的28.5微米和24.1微米。
我们建议进行一系列三次检查，以便在时间和材料使用方面以最佳效率提供高重复性。
