[血小板活化因子类似物的合成]
[Synthesis of platelet activation factor analogs].
作者信息
Sablina M A, Ushakova I P, Dement'eva E V, Dergousov A A, Serebrennikova G A
出版信息
Bioorg Khim. 1993 Mar;19(3):354-9.
PMID:8489534
Abstract
Novel structural analogues of the platelet activating factor (PAF), rac-1-octadecyl-2-allyl-glycerol-3-phosphocholine and rac-1-octadecyl-2-allyl-1-thioglycerol-3-phosphocholine , have been synthesized. The phospholipids obtained showed neither PAF-agonistic nor PAF-antagonistic activity at the concentration of 10(-5) to 10(-7) M.
摘要
已合成血小板活化因子（PAF）的新型结构类似物，即rac-1-十八烷基-2-烯丙基-甘油-3-磷酸胆碱和rac-1-十八烷基-2-烯丙基-1-硫代甘油-3-磷酸胆碱。所获得的磷脂在10^(-5)至10^(-7) M的浓度下既无PAF激动活性也无PAF拮抗活性。
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