Tufenkji A E, Campistron G, Malbosc R, Declume C, Dormard Y, Atabakhsh F, Benard P, Houin G
Laboratoire de Pharmacologie-Pharmacocinétique, Faculté des Sciences Pharmaceutiques, Toulouse, France.
Arzneimittelforschung. 1993 Mar;43(3):323-6.
N-N'-Dicyclopropyl-methyl-piperazine-dichlorhydrate (Ino 2628-CZ) is a novel inotropic compound. The absorption, distribution, excretion and metabolism of radiochemically labelled 14C-Ino 2628-CZ has been studied in male and female rats after intravenous and oral administration. The compound was mainly excreted during the first 24 h after both administrations, although traces of radioactivity were still measured at 7 days post-dose. About 20% of the drug is excreted in the urine unchanged. Nine metabolites were separated, four of them being characterized.
N-N'-二环丙基甲基哌嗪二盐酸盐（Ino 2628-CZ）是一种新型的强心化合物。对放射性化学标记的14C-Ino 2628-CZ在雄性和雌性大鼠静脉内和口服给药后的吸收、分布、排泄和代谢情况进行了研究。两种给药方式后，该化合物主要在最初24小时内排出，不过在给药后7天仍可检测到微量放射性。约20%的药物以原形经尿液排出。分离出了9种代谢物，其中4种已得到表征。
