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14C-N-N'-二环丙基-甲基-哌嗪二盐酸盐的药代动力学。第二篇通讯：大鼠体内的组织分布

Pharmacokinetics of 14C-N-N'-dicyclopropyl-methyl-piperazine-dichlorhydrate. 2nd communication: tissue distribution in rats.

作者信息

Atabakhsh F, Benard P, Declume C, Tufenkji A E, Malbosc R, Campistron G, Houin G

机构信息

Laboratoire de Pharmacologie-Pharmacocinétique, Faculté des Sciences Pharmaceutiques, Toulouse, France.

出版信息

Arzneimittelforschung. 1993 Apr;43(4):436-40.

PMID:8494573
Abstract

The distribution of radioactivity in rats after intravenous or oral administration of 14C-labelled N-N'-dicyclopropyl-methyl-piperazine-dichlorhydrate (14C-Ino 2628-CZ) demonstrated that the labelled compound was widely distributed in the body. An important diffusion of the isotope was found in the central nervous system, the gastric mucosa and several glands. Only small amounts of radioactivity were found in these organs 24 h after dosage.

摘要

静脉注射或口服14C标记的N-N'-二环丙基-甲基-哌嗪二盐酸盐（14C-Ino 2628-CZ）后，大鼠体内放射性分布表明，标记化合物在体内广泛分布。在中枢神经系统、胃黏膜和几个腺体中发现了同位素的重要扩散。给药24小时后，在这些器官中仅发现少量放射性。

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