Stacy M, Cardoso F, Jankovic J
Parkinson's Disease Center, Baylor College of Medicine, Houston, TX 77030.
Neurology. 1993 May;43(5):937-41. doi: 10.1212/wnl.43.5.937.
We reviewed the medical records and videotapes of 100 patients with tardive dyskinesia (TD) referred to our movement disorders clinic to characterize the spectrum of hyperkinetic movement disorders caused by dopamine receptor blocking drugs (DRBD). Tardive stereotypy, present in 78 patients, was the most common type of TD, followed by tardive dystonia, akathisia, tremor, chorea, and myoclonus. Sixty-four had a combination of these hyperkinesias. In a second study, a "blind" review of videotapes of patients with a variety of movement disorders found that DRBD were the cause of stereotypic movements in 89.3% of patients, and 96.1% of patients with TD had stereotypy. We conclude that stereotypy can be readily differentiated from other hyperkinetic movement disorders and that its presence in an adult is highly suggestive of prior exposure to DRBD.
我们回顾了转至我们运动障碍门诊的100例迟发性运动障碍（TD）患者的病历和录像，以明确多巴胺受体阻断药物（DRBD）所致的多动性运动障碍谱。78例患者存在迟发性刻板动作，这是TD最常见的类型，其次是迟发性肌张力障碍、静坐不能、震颤、舞蹈症和肌阵挛。64例患者有这些多动症状的组合。在第二项研究中，对患有各种运动障碍患者的录像进行“盲法”审查发现，DRBD是89.3%患者刻板动作的病因，96.1%的TD患者有刻板动作。我们得出结论，刻板动作可轻易与其他多动性运动障碍相鉴别，并且在成人中出现高度提示既往接触过DRBD。
