Yagoda A, Petrylak D, Thompson S
Medical Oncology Division, Columbia-Presbyterian Medical Center, New York, New York.
Urol Clin North Am. 1993 May;20(2):303-21.
This article reviews 72 cytotoxic chemotherapeutic agents used singly or in a limited number of two drug combinations. Results in 3502 adequately treated patients show objective response (complete and partial remissions) in only 197 or 5.6% (95% CI, 4.8% to 6.4%). Although some data suggest that a few drugs need further evaluation, at this time, renal cell carcinoma must be considered a chemotherapeutically resistant cancer.
本文回顾了72种单独使用或仅以有限的两种药物组合使用的细胞毒性化疗药物。对3502例得到充分治疗的患者的研究结果显示，仅有197例（5.6%，95%置信区间为4.8%至6.4%）出现客观缓解（完全缓解和部分缓解）。尽管一些数据表明少数药物需要进一步评估，但目前，肾细胞癌必须被视为一种化疗耐药性癌症。
