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Antimicrob Agents Chemother. 2016 Jun 20;60(7):4361-3. doi: 10.1128/AAC.02948-15. Print 2016 Jul.

本文引用的文献

1
The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.氯胍及其代谢产物环氯胍和对氯苯双胍在体外对恶性疟原虫的活性。
Ann Trop Med Parasitol. 1984 Jun;78(3):273-8. doi: 10.1080/00034983.1984.11811816.
2
In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test.恶性疟原虫药物敏感性的体外研究：一种新的半微量试验的评估
Am J Trop Med Hyg. 1983 May;32(3):447-51. doi: 10.4269/ajtmh.1983.32.447.
3
A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii.
Ann Trop Med Parasitol. 1985 Jun;79(3):247-51. doi: 10.1080/00034983.1985.11811915.
4
In vitro susceptibility of Plasmodium falciparum isolates from Jilore, Kenya, to antimalarial drugs.肯尼亚吉洛雷恶性疟原虫分离株对抗疟药物的体外敏感性
Am J Trop Med Hyg. 1987 Nov;37(3):445-51. doi: 10.4269/ajtmh.1987.37.445.
5
In vitro activity of antimalarial compounds on the exoerythrocytic stages of Plasmodium cynomolgi and P. knowlesi.抗疟化合物对食蟹猴疟原虫和诺氏疟原虫红细胞外期的体外活性。
Am J Trop Med Hyg. 1989 Mar;40(3):235-9. doi: 10.4269/ajtmh.1989.40.235.
6
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.恶性疟原虫对环氯胍和乙胺嘧啶耐药性差异的分子基础
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3018-22. doi: 10.1073/pnas.87.8.3018.
7
Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.恶性疟原虫二氢叶酸还原酶-胸苷酸合成酶基因中与环氯胍耐药相关的氨基酸不同于与乙胺嘧啶耐药相关的氨基酸。
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3014-7. doi: 10.1073/pnas.87.8.3014.
8
In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil.来自利比里亚的恶性疟原虫分离株对乙胺嘧啶、环氯胍和氯环胍的体外及体内敏感性
Ann Trop Med Parasitol. 1990 Dec;84(6):563-71. doi: 10.1080/00034983.1990.11812511.
9
Prolonged malaria prophylaxis with chloroquine and proguanil (chloroguanide) in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance.在一个氯喹抗性高发的疟疾流行地区，对非免疫常住人群长期使用氯喹和氯胍（氯胍）进行疟疾预防。
Antimicrob Agents Chemother. 1991 Feb;35(2):373-6. doi: 10.1128/AAC.35.2.373.
10
Activity of dihydrofolate reductase inhibitors on the hepatic stages of Plasmodium yoelii yoelii in vitro.二氢叶酸还原酶抑制剂对约氏疟原虫肝脏期的体外活性
Trans R Soc Trop Med Hyg. 1991 Nov-Dec;85(6):725-6. doi: 10.1016/0035-9203(91)90429-3.

环氯胍对恶性疟原虫非洲分离株的体外活性

In vitro activity of cycloguanil against African isolates of Plasmodium falciparum.

作者信息

Basco L K, Ramiliarisoa O, Ringwald P, Doury J C, Le Bras J

机构信息

Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, Paris, France.

出版信息

Antimicrob Agents Chemother. 1993 Apr;37(4):924-5. doi: 10.1128/AAC.37.4.924.

DOI:10.1128/AAC.37.4.924
PMID:8494394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187818/
Abstract

The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.

摘要

采用半微量测定系统评估了环氯胍对86株非洲恶性疟原虫分离株的体外活性。观察到敏感性模式呈双峰分布，44%的分离株对环氯胍敏感。环氯胍单独使用时对某些分离株的红细胞内期仍具有高活性，并且鉴于其对肝期的活性，与氯喹联合使用时可能对化学预防有用。