甲氨蝶呤成功治疗强直性脊柱炎。

Ankylosing spondylitis successfully treated with methotrexate.

作者信息

Yamane K, Saito C, Natsuda H, Yuhara T, Akama T, Suzuki H, Kashiwagi H

机构信息

Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.

出版信息

Intern Med. 1993 Jan;32(1):53-6. doi: 10.2169/internalmedicine.32.53.

DOI:10.2169/internalmedicine.32.53

PMID:8495046

Abstract

A 37-year-old man with ankylosing spondylitis (AS) and psoriasis who was successfully treated with methotrexate (MTX) is reported. In 1980, he had low back pain, limited motion in the lumbar spine, radiological findings of bilateral sacroiliitis, and HLA-B27 positivity. In January 1991, he developed psoriasis and he had difficulty in performing desk work in spite of treatment with antirheumatic drugs. In May 1991, MTX 7.5 mg/week per os was started. Joint symptoms, psoriasis, and acute phase reactants improved within 1 month after the treatment and this improvement continued for more than 6 months after the treatment. After discharge he was able to return to his job.

摘要

报告了一名37岁患有强直性脊柱炎（AS）和银屑病的男性，他接受甲氨蝶呤（MTX）治疗取得成功。1980年，他出现腰痛，腰椎活动受限，双侧骶髂关节炎的影像学表现以及HLA - B27阳性。1991年1月，他患上银屑病，尽管使用了抗风湿药物治疗，但仍难以进行伏案工作。1991年5月，开始口服甲氨蝶呤，每周7.5毫克。治疗后1个月内关节症状、银屑病及急性期反应物均有所改善，且这种改善在治疗后持续了6个月以上。出院后他能够重返工作岗位。